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KMID : 0379119820100010050
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Korean Journal of Mycology
1982 Volume.10 No. 1 p.50 ~ p.50
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Studies on the Constituents of the Higher Fungi of (33)
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Choi Eung-Chil
Kang Chang-Yul
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Abstract
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For the purpose of finding out the stronger antitumor compounds with the lower toxicity from the natural resources, the antitumor activity test of the water extract of the carpophores of Trametes sanguinea (L. ex Fr.) Lloyd, was undertaken. The carpophores of T. sanguinea, a high fungi, were collected in Gyeong Gi Province and extracted with hot water. The extract was purified by dialyzing through Visking tube and a polysaccharide fraction was obtained. The antitumor activity of the fraction was tested against sarcoma 180 implanted in mice.
The tumor inhibition ratio of the polysaccharide fraction against the tumor was 72.4% in the doses of 10㎎/㎏/day for the period of ten days. The tumor in two of the 8 mice was completely regressed.
The components of this aqueous extract were found to be a polysaccharide and a protein by color reactions including Anthrone and Lowry-Folin tests. The chemical analysis of the polysaccharide fraction was also undertaken.
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